120 articles - From Friday Jul 04 2025 to Friday Jul 11 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| J Neurogastroenterol Motil |
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Validation of Lyon 2.0 Gastroesophageal Reflux Disease Consensus: Limited Clinical Utility of Mean Nocturnal Basal Impedance in Koreans. MNBI significantly correlated with AET and LA grades, highlighting its diagnostic value in Korean GERD patients. However, regional variations suggest higher MNBI thresholds than Lyon 2.0 recommendations, warranting further studies to refine criteria for Asian populations. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
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Systematic Review: Incidence of Liver-Related Events in People Living With Hepatitis Delta Virus. The number of studies describing the incidence of liver-related outcomes among people with HDV remains limited. Quantifying incidence of liver-related events can improve our understanding of disease progression and inform potential treatment strategies. |
| Clin Gastroenterol Hepatol |
The Affordable Care Act Improves Access, Survival, and Racial Disparities of Patients with Liver Disease: A Systematic Review. The ACA, particularly ME, improved access, survival, and equity among Medicaid-eligible adults with CLD. Individuals in NME states would likely benefit from expansion, and future liver health policy should consider these findings to reduce disparities. |
| Endosc Int Open |
Bowel preparation assessment using artificial intelligence: Systematic review. AI-BPS can standardize and outperform human bowel preparation evaluation by better correlating with expert BBPS ratings, AMR, ADR, and PDR. Further research following recommended reporting guidelines is needed to allow for cross-study comparisons and meta-analysis, which was not possible in this study due to heterogonous study design and reporting metrics. |
Effectiveness and safety of endoscopic submucosal dissection for residual or recurrent colorectal neoplasia: Meta-analysis. This meta-analysis suggests that ESD is effective and safe for treating residual or recurrent colorectal neoplasia after previous resection, with further prospective validation studies needed to compare ESD with other endoscopic resection methods and surgery in this context. |
Gastroesophageal reflux disease over time in endoscopic versus surgical myotomy for treatment of achalasia: Systematic review and meta-analysis. A higher rate of early GERD is observed in POEM compared with HMF, with the difference waning over time and reaching equivalence after 12 months, despite a higher rate of GAST in the endoscopic group. POEM also exhibited effectiveness and safety comparable to the surgical approach. |
| Gastrointest Endosc |
Postprocedural cholecystitis following covered self-expandable metal stent placement in patients with distal malignant biliary obstruction: a systematic review and meta-analysis. Our study demonstrated higher rates of post-procedural cholecystitis following ERCP with CSEMS placement compared to USEMS. These findings highlight the importance of careful stent selection, particularly in patients with gallbladder in-situ, to optimize patient care, reduce adverse events and prevent delays in oncologic management. |
| J Neurogastroenterol Motil |
Diagnostic Criteria and Symptom Profiles in Adult Idiopathic Gastroparesis: A Systematic Review. The findings highlight the inherent diagnostic challenges and underscores the need for confirming delayed gastric emptying to clinch an accurate diagnosis of gastroparesis. Future research should focus on developing consistent diagnostic criteria across diverse populations to improve the diagnosis and management of idiopathic gastroparesis. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Effectiveness and Safety of First-Line Non-Bismuth Quadruple Concomitant Therapy Versus Single-Capsule Bismuth Quadruple Therapy. Sc-BQT is more effective, better tolerated, and more broadly applicable than 14-day CT. Both regimens achieved ≥ 90% success, but Sc-BQT's stewardship-friendly profile further supports its use as first-line therapy for H. pylori eradication. |
MELD 3.0 Improves Risk Stratification and Mortality Prediction in Hepatorenal Syndrome-Acute Kidney Injury: A Multicentre Study. This is the first large-scale study to validate MELD 3.0 in HRS-AKI. By offering enhanced discrimination and clinically meaningful reclassification, MELD 3.0 provides a more refined tool for early risk stratification, with potential to guide timely intervention, inform transplant decisions and improve personalized care in this critically ill population. |
| Am J Gastroenterol |
Early Improvement of Mental Health is Associated with Long-term Disease Remission in Ulcerative Colitis. Early mental health improvements independently predicted long-term disease remission. Integrating mental health assessments into UC management strategies may provide valuable insights beyond physical symptoms. |
Fecal Immunochemical Test (FIT) Completion by Instruction Type: A Randomized Clinical Trial Comparing QR-Code linked Video to Pictorial Instructions. Providing QR-code based education offers a promising format for delivering low literacy instructions, which might be a practical strategy to improve FIT completion for CRC screening. |
Local post-procedural cryoprevention significantly reduces the incidence of post-ERCP pancreatitis: a multicenter randomized controlled trial. Cryoprevention using ice water significantly reduced PEP incidence, demonstrating a safe, effective, and low-cost strategy. This approach offers a practical alternative, where NSAID use is limited. |
Post-Colonoscopy Colorectal Cancer in Fecal Immunochemical Test-Positive Individuals: Prevalence, Predictors, and Root-Cause Analysis in a Nationwide Cohort. Among FIT-positive individuals, the PCCRC-3y rate was 6.4%, with missed lesions and incomplete resection as key contributors. These findings provide useful information on quality metrics in FIT-based CRC screening programs. |
Safety of early oral refeeding in patients with chronic pancreatitis after extracorporeal shock wave lithotripsy of pancreatic stone (SHEEL): A multicenter randomized controlled trial. Early oral refeeding in patients after ESWL was safe and did not increase the incidence of post-ESWL pancreatitis. This was also associated with reduced abdominal discomfort and hunger. |
| Clin Gastroenterol Hepatol |
An International Multicenter Study of Native and Immigrant South Asian Crohn's Disease. Our international, multicenter study identified both commonalities as well as unique differences in disease phenotype, behavior, serological patterns and environmental factors by geography and immigrant status. We highlight the importance of changing environment on CD phenotypic expression. |
Efficacy of 6-mm and 8-mm transjugular intrahepatic portosystemic shunt for variceal bleeding: a randomized controlled trial. Among this cohort of patients with cirrhosis who are receiving TIPS for the secondary prevention of variceal bleeding, the use of 6-mm stents results in a higher rate of rebleeding but has similar survival and a significantly lower risk of OHE compared to 8-mm stents. |
Efficacy of etrasimod in ulcerative colitis: analysis of ELEVATE UC 52 and ELEVATE UC 12 by baseline endoscopic severity. Etrasimod demonstrated significant induction and maintenance efficacy over placebo in both moderate and severe endoscopic disease. Response to etrasimod in patients with severe endoscopic disease may continue to improve beyond 12-week induction therapy (ClinicalTrials.gov NCT03945188; NCT03996369). |
Liver Failure, Hepatic Encephalopathy, and Infection Contribute to Mortality Risk in a Global Cirrhosis Cohort. Cutoffs associated with mortality are admission bilirubin >7.5 mg/dl, INR >1.5, creatinine > 1.5 mg/dL; MELD >27 and MELD3.0 >28. Liver failure may therefore be identified by the serum bilirubin>7.5mg/dL and INR>1.5, with hepatic encephalopathy and admission infections as contributors towards mortality. |
Nasal CPAP to Reduce Hypoxia in Patients with Obesity Undergoing Sedated Upper GI Endoscopy: A Prospective Randomized Trial. nCPAP significantly reduces hypoxia risk and stabilizes oxygen saturation in patients with obesity undergoing sedated upper GI endoscopy, supporting its routine use in these high-risk patients. Further studies should explore its broader clinical application. |
Risk factors of metabolic dysfunction-associated steatotic liver disease in a cohort of patients with chronic hepatitis B. In this large European cohort, MASLD and fibrosis were highly prevalent among CHB, while MASLD aggravated liver fibrosis. Though screening strategies remain inconsistent, ferritin levels, increased BMI and T2DM may inform on the presence of MASLD. Biomarkers showed modest performance in predicting fibrosis. |
| Endosc Int Open |
Bridging the gap in gastrointestinal healthcare in a resource-limited setup: Feasibility study of weekend endoscopy services in Southwest Ethiopia. The study demonstrates the feasibility and effectiveness of a weekend outreach endoscopy service led by a trained gastroenterologist in a rural Ethiopian setting. The unexpectedly high prevalence of upper gastrointestinal disorders, including cancers, and the long duration of symptoms before endoscopy likely reflect delayed diagnoses due to limited access to endoscopy. Moreover, presence of alarm symptoms predicted major endoscopic findings. Expanding endoscopy services, increasing public awareness, and further research into risk factors and preventive strategies for these diseases are recommended. |
Comparing ChatGPT3.5 and Bard recommendations for colonoscopy intervals: Bridging the gap in healthcare settings. This study highlights the limitations of freely available LLMs in assisting colonoscopy screening recommendations. Although the potential of freely available LLMs to offer uniformity is significant, the low accuracy, as noted, excludes their use as the sole agent in providing recommendations. |
Diagnostic performance and agreement of auditors for evaluation of computer-aided optical polyp diagnosis: Prospective study. Expert audit for evaluating CADx resulted in high sensitivity and interobserver agreement for high-confidence adenomas. Audit by two experts, with a third expert for arbitration, permitted audit of al polyps and effective assessment of CADx within clinical studies. |
Endoscopic mucosal resection for Barrett's neoplasia: Long-term outcomes from the largest Canadian single-center experience. While the success rate of EMR for BE is excellent, this study highlights substantial long-term risk of neoplastic recurrence, underscoring the need for indefinite surveillance for patients who had HGD or EAC. |
Endoscopic retrograde cholangiopancreatography services in Sudan during wartime: Innovations in crisis. Development of a local scoring system for trainee assessment after 50 supervised procedures aims to establish a sustainable ERCP fellowship program, addressing the shortage of specialists. These efforts highlight resilience and innovation in delivering ERCP services during conflict. |
Ex vivo evaluation of a novel through-the-scope traction device for endoscopic submucosal dissection. TRACMOTION significantly improves the efficiency of ESD, reducing procedure time and complication rates. This traction device could potentially facilitate broader adoption of ESD in clinical practice. However, further research in human trials is necessary to validate these findings. |
Feasibility of real-time artificial intelligence-assisted anatomical structure recognition during endoscopic submucosal dissection. In this proof-of-concept study, feasibility of a real-time AI algorithm for anatomical structure delineation and orientation support during ESD was evaluated. The application proved safe and appropriate for routine procedures in humans. Further studies are needed to elucidate a potential clinical benefit of this new technology. |
Implementing endoscopy video recording in routine clinical practice: Strategies from three tertiary care centers. By describing successful strategies, we aim to inspire gastroenterology divisions worldwide to adapt routine video recording for endoscopy procedures, thereby increasing the volume and diversity of datasets necessary for developing clinically impactful AI applications. |
Mobile health technology in quality assessment of pediatric ileocolonoscopy: Results of the SIGENP national program. mHealth was effective in assessing the quality of pediatric endoscopy. Levels of bowel preparation, sedation, TI intubation rate, and safety were adequate in Italy, whereas waiting time and post-procedure communication seemed to be the most critical areas of concern. |
Retrospective study comparing rectal endoscopic submucosal dissection with and without Foley catheter drainage tube placement. Foley catheter placement notably improved efficiency of rectal ESD performed by novice endoscopists, particularly by increasing dissection speed. This technique may contribute to safer and more effective ESD. However, larger studies are needed to confirm these findings and further assess their benefits. |
| Endoscopy |
Devices and techniques for bariatric and metabolic endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review. The paper emphasizes the necessity for additional high quality randomized controlled trials and long-term outcome data to better define the role of these therapies within obesity treatment protocols. Overall, this review serves as an authoritative resource for endoscopists, bariatric specialists, and the wider healthcare community involved in obesity care, promoting best practices and guiding the appropriate implementation of EBMTs in clinical settings. |
Multicenter validation of a cholangioscopy artificial intelligence for evaluation of biliary tract disease. A previously developed cholangioscopy AI was found to continually outperform standard ERCP sampling modalities for accurate identification of malignancy without additional retraining in a multicenter validation cohort. |
Two-sample Fecal Immunochemical Testing as a Tool to avert Colonoscopy in Symptomatic Patients - A prospective multicenter cohort study. Two-sample FIT can achieve a NPV of 99.3% for IBD and 95.6% for AN with a sensitivity of 83.3% and 71.7% respectively. Concordant negative results were found in 71.1%. However, 28.3% of AN was still missed. Therefore, two-sample FIT may play a role in determining the need for colonoscopy in symptomatic patients, but it misses too many lesions to be used as the sole determinant to avert colonoscopy. |
| Gastroenterology |
Chemical perturbations impacting histone acetylation govern colorectal cancer differentiation. Our findings establish histone acetylation as a chemically targetable mechanism governing CRC cell fate and demonstrate that epigenetic reprogramming can be leveraged as a therapeutic strategy. By identifying HDAC½ inhibition as a driver of differentiation and revealing H3K27ac as a key regulatory mark, this study provides a framework for targeting chromatin-modifying enzymes to counteract CRC plasticity and improve treatment outcomes. |
Dietary Patterns and Incident Chronic Constipation in Three Prospective Cohorts of Middle- and Older-aged Adults. Our findings suggest that dietary patterns emphasizing plant-based foods and healthy fats may protect against constipation, informing future dietary interventions and treatments for chronic constipation. |
Peyer's patch B cells sample transglutaminase-gluten complexes and drive celiac disease autoimmunity. The model supports a mechanism where TG2-gluten complexes formed in the gut lumen are taken up by TG2-specific B cells in GALT. We propose that this pathway plays an important role in driving the anti-TG2 IgA autoantibody response in celiac disease patients. The model provides a platform to explore novel approaches for celiac disease therapies. |
RISK OF PANCREATIC CANCER IN GLYCEMICALLY DEFINED NEW-ONSET DIABETES: A PROSPECTIVE COHORT STUDY. Glycemically defined new-onset diabetes, identifiable in real-time using active surveillance of electronic health records, is associated with a high 3-year incidence of pancreatic cancer with marked racial/ethnic differences. Longer term risk needs further study. |
| Gastrointest Endosc |
Clinical Characteristics Analysis of Anorectal Function Changes After Endoscopic Submucosal Dissection for Rectal Lesions. The occurrence of anorectal symptoms following rectal ESD is closely related to the location and size of the lesion. The psychological and quality-of-life impairments caused by these symptoms are primarily short-term and can gradually recover over time. |
Feasibility and safety of endoscopic submucosal dissection for the anal canal lesions. The favorable short- and long-term outcomes indicate ESD is a safe, effective, and attractive therapeutic modality for ACLs. A multicenter and prospective study should be conducted to validate this technology. |
Risk factors of bleeding ulceration after argon plasma coagulation in patients with radiation-associated vascular ectasias. Rectal EQD2 D10cc ≥70 Gy is an independent risk factor for bleeding ulceration after APC for RAVE. In multidisciplinary management involving therapeutic radiologists, endoscopists may consider non-ablative treatment instead of APC in patients with rectal EQD2 D10cc ≥70 Gy. |
| Gut |
Crohn's disease and ulcerative colitis exhibit prediagnostic antibody signatures with shared and divergent changes towards disease onset. This study is the first comprehensive high-resolution analysis of the exact antigenic nature of systemic antibody responses during the transition from prediagnostic to established IBD. The antibody signatures we found may represent a route to developing biomarkers that identify individuals at high risk of developing disease. |
| Hepatology |
Aging disrupts hepatocyte zonation homeostasis in mice and humans. These findings reveal that aging causes loss of distinct hepatic zonation and alters intercellular communication through widespread transcriptional and architectural remodeling of liver cell types. The emergence of bi-zonal hepatocytes and expansion of hepatic zones in aged livers represent key hallmarks of hepatic aging. Our study provides new insights into mechanisms of liver aging and may inform therapeutic strategies targeting age-associated liver dysfunction. |
Biliary YB-1/GLI2 axis facilitates ductular reaction and promotes hepatic stellate cell activation via SPP1/Integrin αvβ1 signaling during liver fibrogenesis. YB-1/GLI2 axis promotes DRC proliferation and SPP1 secretion, which facilitates HSC activation through integrin αvβ1 receptors. This study highlights the YB-1/GLI2/SPP1 signaling pathway as a potential target for therapeutic intervention in liver fibrosis. |
Environmental Risk Factors for Liver Cancer. A number of other environmental factors have been studied for an association with liver cancers, such as air pollution, per- and polyfluoroalkyl substances, cyanobacteria, pesticides, aristolochic acid, polycyclic aromatic hydrocarbons, asbestos, arsenic, and organic solvents, however limited evidence exists for these exposures. It is the goal of this review article to examine what is currently known about environmental risk factors and liver cancer and suggest which ones should have the highest priority for further research. |
Liver resection with and without vascular resection versus transplantation for de novo perihilar cholangiocarcinoma. Both LR and RT+LT achieve excellent oncological outcomes in selected de novo pCCA patients. Key challenges remain dropouts during neoadjuvant therapy in patients planned for LT and high perioperative mortality for patients undergoing LR. OS doubles in LR+VR patients compared to dropouts, supporting LR+VR as a viable option for LT-ineligible patients. Appropriate patient selection is crucial, as those not undergoing surgery suffer from a dismal prognosis. |
Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multi-center cirrhosis outpatient cohort. In a multi-center North American outpatient cirrhosis cohort with controlled etiologies, serum metabolomics and salivary microbiome add to clinical variables to prognosticate 6-month hospitalization. |
| J Hepatol |
Prevalence, severity and determinants of steatotic liver disease among individuals with metabolic and alcohol risk from the community. Among individuals with cardiometabolic and/or alcohol risk factors, 70% had SLD, 10% had elevated liver stiffness, and 2% had biopsy-confirmed advanced liver fibrosis. NCT03308916 IMPACT AND IMPLICATIONS Steatotic liver disease (SLD) remains underdiagnosed in the general population. This study provides new population-based data on its prevalence and severity among individuals with metabolic and/or alcohol-related risk. These findings are relevant to clinicians, researchers, and public health planners, as prevalence data are essential to inform evolving screening strategies. Methodological limitations, including the cross-sectional design and limited generalizability, should be considered when interpreting the results. |
Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation. Cideb deletion is more protective in some types of fatty liver disease. β-oxidation is an important component of the Cideb protective mechanism. CIDEB inhibition represents a promising approach, and somatic mutations in CIDEB might predict the patient populations that might benefit the most. Impact and implications It is not clear why somatic and germline CIDEB mutations are protective in MASLD. Cideb mutations are predominantly loss of function, and Cideb-deficient clones selectively expand in specific dietary contexts such as CDA-HFD-induced MASLD. Consistently, liver-wide deletion of Cideb ameliorates MASLD most profoundly after CDA-HFD feeding. Mechanistically, Cideb deficiency enhances hepatic fatty acid β-oxidation via ATGL and PPARα activation. These findings suggest that CIDEB inhibition might be most effective in patients with the subtypes of MASLD that promote the expansion of CIDEB mutant clones. |
Spatiotemporal liver dynamics shape hepatocellular heterogeneity and impact in vivo gene engineering. These insights into spatiotemporal hepatocyte dynamics enhance our understanding of liver biology and have important implications for therapeutic strategies. Impact and implications We provide new insights into the spatiotemporal dynamics of the mouse liver during postnatal growth, highlighting both proliferative and transcriptomic heterogeneity among hepatocytes and their impact on the efficiency and distribution of in vivo lentiviral gene delivery and targeted gene editing. Understanding and manipulating the biological processes behind this heterogeneity can enhance gene transfer outcomes. We report that not al hepatocytes contribute equally to liver growth, indicating that effectively targeting clonogenic hepatocytes in the newborn liver is crucial for the long-term maintenance of therapeutic genetic modifications. Furthermore, this phenomenon can be leveraged to expand the pool of genetically corrected cells, as illustrated here by a targeted gene editing strategy. Finally, we reveal the existence of a tissue niche that supports the proliferation of both clonogenic hepatocytes and hematopoietic progenitors in neonatal livers. Gaining a deeper understanding of this niche and its signals could be beneficial for regenerative purposes. |
| J Neurogastroenterol Motil |
Assessing Treatment Outcomes in Achalasia Using 4-Dimensional High-resolution Impedance Manometry. IBP and clearance ratio help to identify abnormal barium retention in patients after treatment. 4D manometry can be an alternative or complementary approach to characterize and assess treatment response of Achalasia, in additional to TBE or functional lumen imaging probe. |
Assessment of Small Bowel Motility Using Cine-magnetic Resonance Imaging in Patients Suspected With Chronic Intestinal Pseudo-obstruction. Cine-MRI is useful in assessing SB motility that cannot be detected on CT. Its usefulness extends to aiding surgical decision-making, particularly in differentiating between FHAM and CIPO. |
Association Between Psychological Burden and Unexplained High Upper Esophageal Sphincter Basal Pressure. Elevated UES basal pressure is more frequently seen in symptomatic patients with high esophageal hypervigilance and anxiety. When encountering patients with unexplained high UES basal pressure, psychological burden may play a potential role in these cases. |
Clinical Characteristics and Associated Factors in Mexican Patients With Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis Syndrome. This study presents the first detailed analysis of CVS and CHS in the Mexican population, revealing some demographic and clinical differences from global data. These findings highlight the importance of developing region-specific guidelines for diagnosing and managing these conditions, especially given Mexico's changing cannabis policies. |
Long-term Effects of Potassium-competitive Acid Blockers and Proton Pump Inhibitors on Gastrin, Gastric Emptying Rate, and Small Intestinal Microbiota in Rats. Long-term administration of P-CABs and PPIs altered gastrin levels, GE, and gut microbiota. Therefore, the acid suppression-related adverse effects of P-CABs and PPIs are expected to be similar. |
Real-world Application of the Chicago Classification Version 4.0 for Esophageal Manometry: Asian Multicenter Study. We observed heterogeneity among centers in the application of CC v4.0 protocol. To increase inter-center reliability and minimize diagnostic ambiguity, efforts should continue toward the practical clinical application of standard protocols. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Endosc Int Open |
| Gastroenterology |
| J Hepatol |
Mechanisms and Management of Graft In- and Out-flow in Liver Transplantation: A Narrative Review of the Literature and Guide for Interventional Management. Overall, an understanding of complex hepatic vascular regulation is essential to optimizing liver graft function in transplantation. This review may help surgeons as they continue to strive for improved access to transplantation across the world. |
| J Neurogastroenterol Motil |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Gastroenterology |
| J Hepatol |
| J Neurogastroenterol Motil |